The phenomenon of homicide followed by suicide (HS) has a low prevalence worldwide, although the literature has identified that these cases represent a significant percentage in homicide subtypes such as intimate partner homicide or filicide. In the present study, HS (n = 41) and homicides in which the perpetrator did not commit suicide after the event (n = 556) are compared. The information was extracted from police reports of homicides committed in Spain between 2010 and 2012 and belonging to the jurisdictions of the National Police and Civil Guard. The results showed that out of the total number of homicides analyzed, HS accounted for 4.9%, which implies a rate of 0.05 per 100,000 inhabitants. The findings of the study show that the profile of a HS victim of a 52-year-old Spanish woman. The perpetrator is of Spanish origin, 50 years old, unemployed, or retired, with a mental disorder, and with substance use being uncommon at the time of the event. HS events take place at the perpetrator's home, are related to interpersonal conflicts, involve a single perpetrator, several victims, and are mainly committed with a firearm. The findings are mostly consistent with previous studies and the prevalence of HS in the couple setting is highlighted (56.5%). However, the importance of studying cases outside of this setting is emphasized since it has been found that 30.5% of cases involve other family relationships and 13% occurred outside the domestic sphere.