Biomaterial Database

Mitochondrial Protein Network: From Biogenesis to Bioenergetics in Health and Disease. 2020

Alessandra Ferramosca

Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.

Mitochondria are double membrane-bound organelles which are essential for the viability of eukaryotic cells, because they play a crucial role in bioenergetics, metabolism and signaling [...].

UI	MeSH Term	Description	Entries
D008928	Mitochondria	Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)	Mitochondrial Contraction,Mitochondrion,Contraction, Mitochondrial,Contractions, Mitochondrial,Mitochondrial Contractions
D004272	DNA, Mitochondrial	Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.	Mitochondrial DNA,mtDNA
D004734	Energy Metabolism	The chemical reactions involved in the production and utilization of various forms of energy in cells.	Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D024101	Mitochondrial Proteins	Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.	Proteins, Mitochondrial,Mitochondrial Protein,Protein, Mitochondrial
D028361	Mitochondrial Diseases	Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.	Electron Transport Chain Deficiencies, Mitochondrial,Mitochondria Dysfunction,Mitochondrial Defect,Mitochondrial Dysfunction,Oxidative Phosphorylation Deficiencies,Respiratory Chain Deficiencies, Mitochondrial,Mitochondrial Disorders,Mitochondrial Electron Transport Chain Deficiencies,Mitochondrial Respiratory Chain Deficiencies,Defect, Mitochondrial,Deficiency, Oxidative Phosphorylation,Disease, Mitochondrial,Disorder, Mitochondrial,Dysfunction, Mitochondria,Dysfunction, Mitochondrial,Mitochondria Dysfunctions,Mitochondrial Defects,Mitochondrial Disease,Mitochondrial Disorder,Mitochondrial Dysfunctions,Oxidative Phosphorylation Deficiency,Phosphorylation Deficiency, Oxidative
D063269	Mitochondrial Turnover	The cellular processes involved in adjustments to the MITOCHONDRIAL VOLUME, content, and activity, that depend on the energy demands of the cell.	Turnover, Mitochondrial