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We carried out a total of 36 in vivo chemosensitivity tests in 33 cases of human malignant tumor using the subrenal capsule assay, developed by A.E. Bogden et al. Of the 36 assays, 31 were evaluable. The chemosensitivity of each tumor varied individually. UFT, 5-fluorouracil, mitomycin-C and adriamycin were administered to gastrointestinal cancer patients regularly, but our SRC-assay showed a high sensitivity rate for UFT and 5-fluorouracil but a low sensitivity rate for mitomycin-C and adriamycin. Nine patients had clinically evaluable lesions and a correlation between the assay results and clinical response existed in 6 cases. The true positive rate was 50% (3/6), the true negative rate 100% (3/3), and the overall predictive accuracy 66% (6/9). This study suggested that 6-day SRC assay is useful for selecting effective anti-tumor agents for the treatment of cancer patients.
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
April 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
March 1984,
Cancer treatment reviews,
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
June 1984,
Cancer research,
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
October 1989,
The Journal of urology,
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
January 1988,
Zentralblatt fur Gynakologie,
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
January 1988,
Journal of medicine,
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
April 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
January 1988,
Progress in clinical and biological research,
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
July 1981,
Cancer,
E Yokoyama, and
N Irimajiri, and
M Shirakabe, and
M Matsumoto, and
J Haneda, and
T Kusunoki, and
J Utsunomiya
February 1984,
Gynecologic oncology,
