Biomaterial Database

IMGT® Biocuration and Comparative Analysis of Bos taurus and Ovis aries TRA/TRD Loci. 2020

Perrine Pégorier, and Morgane Bertignac, and Viviane Nguefack Ngoune, and Géraldine Folch, and Joumana Jabado-Michaloud, and Véronique Giudicelli, and Patrice Duroux, and Marie-Paule Lefranc, and Sofia Kossida

IMGT®, The International ImMunoGeneTics Information System®, Institut de Génétique Humaine (IGH), Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM), 34000 Montpellier, France.

The adaptive immune response provides the vertebrate immune system with the ability to recognize and remember specific pathogens to generate immunity, and mount stronger attacks each time the pathogen is encountered. T cell receptors are the antigen receptors of the adaptive immune response expressed by T cells, which specifically recognize processed antigens, presented as peptides by the highly polymorphic major histocompatibility (MH) proteins. T cell receptors (TR) are divided into two groups, αβ and γδ, which express distinct TR containing either α and β, or γ and δ chains, respectively. The TRα locus (TRA) and TRδ locus (TRD) of bovine (Bos taurus) and the sheep (Ovis aries) have recently been described and annotated by IMGT® biocurators. The aim of the present study is to present the results of the biocuration and to compare the genes of the TRA/TRD loci among these ruminant species based on the Homo sapiens repertoire. The comparative analysis shows similarities but also differences, including the fact that these two species have a TRA/TRD locus about three times larger than that of humans and therefore have many more genes which may demonstrate duplications and/or deletions during evolution.

UI	MeSH Term	Description	Entries
D002417	Cattle	Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.	Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species
D056426	Genetic Loci	Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.	Genetic Locus,Loci, Genetic,Locus, Genetic
D056704	Adaptive Immunity	Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. It can result from either previous infection with that agent or vaccination (IMMUNITY, ACTIVE), or transfer of antibody or lymphocytes from an immune donor (IMMUNIZATION, PASSIVE).	Acquired Immunity,Hybrid Immunity,Adaptive Immune Response,Adoptive Immunity,Immunity, Adaptive,Hybrid Immunities,Immune Response, Adaptive,Immunity, Acquired,Immunity, Adoptive,Immunity, Hybrid,Response, Adaptive Immune
D058977	Molecular Sequence Annotation	The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.	Gene Annotation,Protein Annotation,Annotation, Gene,Annotation, Molecular Sequence,Annotation, Protein,Annotations, Gene,Annotations, Molecular Sequence,Annotations, Protein,Gene Annotations,Molecular Sequence Annotations,Protein Annotations,Sequence Annotation, Molecular,Sequence Annotations, Molecular
D019143	Evolution, Molecular	The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.	Molecular Evolution,Genetic Evolution,Evolution, Genetic
D019673	Genes, T-Cell Receptor alpha	DNA sequences encoding the alpha chain of the T-cell receptor. The genomic organization of the TcR alpha genes is essentially the same in all species and is similar to the organization of Ig genes.	T-Cell Receptor alpha Genes,TcR alpha Genes,T-Cell Receptor alpha-Chain Genes,Gene, TcR alpha,Genes, T Cell Receptor alpha,Genes, TcR alpha,T Cell Receptor alpha Chain Genes,T Cell Receptor alpha Genes,TcR alpha Gene
D019676	Genes, T-Cell Receptor delta	DNA sequences encoding the delta chain of the T-cell receptor. The delta-chain locus is located entirely within the alpha-chain locus.	T-Cell Receptor delta Genes,TcR delta Genes,T-Cell Receptor delta-Chain Genes,Gene, TcR delta,Genes, T Cell Receptor delta,Genes, TcR delta,T Cell Receptor delta Chain Genes,T Cell Receptor delta Genes,TcR delta Gene
D034561	Sheep, Domestic	A species of sheep, Ovis aries, descended from Near Eastern wild forms, especially mouflon.	Mouflon,Ovis ammon aries,Ovis aries,Ovis aries musimon,Ovis gmelini musimon,Domestic Sheep,Mouflons