-transparent.png){kind=logo}
A sonicated liposome suspension of gamma-aminobutyric acid (GABA) and phosphatidylserine (liposome-entrapped GABA), intraperitoneally administered in rats, inhibited EEG epileptic activity induced by penicillin, whereas GABA did not. A significant increase (20.4%) in brain radioactivity accumulation occurred at 5 min after i.p. administration of [14C]GABA associated with phosphatidylserine in comparison with the administration of [14C]GABA; such an increase persisted after 20 min. However, the accumulation of radioactivity into brain synaptosomes demonstrated a 24.1% increase at 5 min and subsequently showed a 43.3% increase at 20 min after injection of liposome-entrapped GABA. The above findings suggest that phosphatidylserine stimulates exogenous GABA uptake into brain GABAergic nerve terminals.
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
February 2008,
Toxicology,
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
June 1975,
Journal of neurochemistry,
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
April 2005,
Neurochemical research,
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
June 1981,
Biochemical pharmacology,
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
December 1976,
Nature,
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
November 1981,
Biulleten' eksperimental'noi biologii i meditsiny,
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
October 1979,
Neuroscience letters,
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
September 1992,
European journal of pharmacology,
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
November 1992,
The Journal of pharmacy and pharmacology,
C Loeb, and
U M Marinari, and
E Benassi, and
G Besio, and
D Cottalasso, and
A Cupello, and
M Maffini, and
P Mainardi, and
M A Pronzato, and
P A Scotto
April 1992,
Pharmacology, biochemistry, and behavior,
