-transparent.png){kind=logo}
PAF-acether (PAF) is a newly formed mediator not normally present in circulating blood. A compound exhibiting all of its biological characteristics but coeluting with phosphatidylcholine (PC) in high-pressure liquid chromatography (HPLC) was unveiled ('peak X') in normal human plasma. A second HPLC run of peak X HPLC fractions revealed the presence of PAF itself with concomitant disappearance of peak X. Beside PAF, immunoreactive apolipoproteins A-I and E were found in peak X. Also lipoproteins (Ls) purified using either ultracentrifugation or immunoaffinity chromatography yielded peak X and, in a second HPLC run, authentic PAF. L-free plasma was devoid of peak X. Finally, after preincubation with plasma, labeled PAF was found associated with Ls. Thus in human blood preformed PAF is bound in high amounts to Ls, a result of interest given the role of Ls and platelets in vascular diseases and the present knowledge on PAF biosynthesis.
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
October 1988,
Biochimica et biophysica acta,
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
December 1982,
Agents and actions,
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
January 1987,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
January 1989,
Agents and actions,
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
March 1982,
Thrombosis research,
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
November 1991,
International immunology,
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
December 1984,
Agents and actions,
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
January 1988,
Progress in biochemical pharmacology,
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
April 1992,
Gastroenterology,
J Benveniste, and
D Nunez, and
P Duriez, and
R Korth, and
J Bidault, and
J C Fruchart
December 1982,
Agents and actions,
