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Chronic nutritional injury was induced in rats by a high-fat, lipotrope-deficient diet. The hepatoprotective effect of 16,16-dimethyl prostaglandin E2 on the deposition of collagen and fat was assessed by histological evaluation and measurement of hydroxyproline. Dose-response studies established that optimal protection was achieved by the twice daily administration of 16,16-dimethyl prostaglandin E2 at 100 micrograms per kg (subcutaneous) or 250 micrograms per kg (oral). 16,16-Dimethyl prostaglandin E2 and a crystalline analog [(p-acetamidobenzamido)phenyl ester of 16,16-dimethyl prostaglandin E2 significantly delayed both the deposition of collagen and the increase in hepatic hydroxyproline content. There was an excellent correlation between the histological assessment of collagen and the biochemical measurement of hydroxyproline. These data provide a rationale for the evaluation of prostaglandins in the treatment of human liver disease.
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
October 1987,
The Journal of laboratory and clinical medicine,
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
March 1982,
Prostaglandins,
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
March 1997,
Digestive diseases and sciences,
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
January 1986,
Hepatology (Baltimore, Md.),
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
April 1992,
Gastroenterology,
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
October 1983,
The Journal of endocrinology,
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
March 1987,
Radiation research,
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
April 1986,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
May 1981,
The Journal of surgical research,
M J Ruwart, and
B D Rush, and
K F Snyder, and
K M Peters, and
H D Appelman, and
K S Henley
January 1983,
Advances in prostaglandin, thromboxane, and leukotriene research,
