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The false neurotransmitter metaraminol has been 18F labeled and evaluated as a possible heart imaging agent on the basis of its selective accumulation in adrenergic nerves. Reaction of 6-(acetoxymercurio)-N-t-BOC-metaraminol with acetyl hypofluorite followed by removal of the BOC group provides a regiospecific synthesis of 6-fluorometaraminol (4). Use of acetyl hypo[18F]fluorite gives [18F]-4 in 60 min in 20-42% radiochemical yield. Systemic blockade of the neuronal uptake-1 carrier with desmethylimipramine or systemic destruction of the adrenergic nerves with 6-hydroxydopamine lowers [18F]-4 accumulation greater than or equal to 85% in all four regions of the rat heart. These preliminary findings suggest that [18F]-4 could be used to assess neuronal damage in various heart diseases by positron emission tomography.
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
April 2000,
Nuclear medicine and biology,
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
March 2001,
Bioorganic & medicinal chemistry,
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
October 1993,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
April 2022,
Pharmaceuticals (Basel, Switzerland),
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
July 1992,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
January 1969,
Experientia,
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
February 2022,
Redox biology,
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
May 2014,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
January 1971,
Federation proceedings,
S G Mislankar, and
D L Gildersleeve, and
D M Wieland, and
C C Massin, and
G K Mulholland, and
S A Toorongian
July 2020,
European journal of nuclear medicine and molecular imaging,
