Biomaterial Database

Congenital malaria by Plasmodium falciparum. 2020

José Gabriel Del Castillo Calderón, and Angie Milena Cárdenas Silva

Hospital Infantil Los Ángeles, Colombia.

Introdution: Congenital malaria (CM) is a Plasmodium spp infection acquired in utero or during delivery with nonspecific clinical manifestations. Plasmodium falciparum can cause severe illness in pregnant wo men and newborns. OBJECTIVE to describe two cases of CM caused by Plasmodium falciparum, di fferential diagnosis of sepsis in newborns of pregnant women who live in or have visited endemic malaria zones. METHODS Female neonates born in a non-endemic malaria area, diagnosed with neonatal sepsis and treated with antibiotics without clinical response. After the first week of life, the peripheral blood smear identified trophozoites of Plasmodium falciparum thus the newborns were treated with intravenous quinine, improving their condition. The mothers of the two newborns who had malaria in pregnancy, one of them received treatment and she was asymptomatic, and the other one had severe malaria at the time of delivery. CONCLUSIONS CM can cause severe neonatal disease with non-specific, sepsis-like clinical manifestations in which early treatment decreases the risk of complicated malaria. It is a differential diagnosis in newborns of women with a history of malaria during pregnancy or pregnant women visiting or living in endemic malaria areas.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D003937	Diagnosis, Differential	Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.	Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071074	Neonatal Sepsis	Blood infection that occurs in an infant younger than 90 days old. Early-onset sepsis is seen in the first week of life and most often appears within 24 hours of birth. Late-onset occurs after 1 week and before 3 months of age.	Neonatal Early-Onset Sepsis,Neonatal Late-Onset Sepsis,Sepsis, Neonatal,Early-Onset Sepses, Neonatal,Early-Onset Sepsis, Neonatal,Late-Onset Sepses, Neonatal,Late-Onset Sepsis, Neonatal,Neonatal Early Onset Sepsis,Neonatal Early-Onset Sepses,Neonatal Late Onset Sepsis,Neonatal Late-Onset Sepses,Neonatal Sepses,Sepses, Neonatal,Sepses, Neonatal Early-Onset,Sepses, Neonatal Late-Onset,Sepsis, Neonatal Early-Onset,Sepsis, Neonatal Late-Onset
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000962	Antimalarials	Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)	Anti-Malarial,Antimalarial,Antimalarial Agent,Antimalarial Drug,Anti-Malarials,Antimalarial Agents,Antimalarial Drugs,Agent, Antimalarial,Agents, Antimalarial,Anti Malarial,Anti Malarials,Drug, Antimalarial,Drugs, Antimalarial
D015597	Pregnancy Complications, Parasitic	The co-occurrence of pregnancy and parasitic diseases. The parasitic infection may precede or follow FERTILIZATION.	Parasitic Pregnancy Complications,Complications, Parasitic Pregnancy,Pregnancy, Parasitic Complications,Complication, Parasitic Pregnancy,Complications Pregnancies, Parasitic,Complications Pregnancy, Parasitic,Parasitic Complications Pregnancies,Parasitic Complications Pregnancy,Parasitic Pregnancy Complication,Pregnancies, Parasitic Complications,Pregnancy Complication, Parasitic
D016778	Malaria, Falciparum	Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	Plasmodium falciparum Malaria,Malaria, Plasmodium falciparum