-transparent.png){kind=logo}
We evaluated the effect of beta-aminopropionitrile (beta APN) on the nitrogen dioxide (NO2) animal model of emphysema. Rats maintained on a beta APN-supplemented or a regular diet were exposed to 30 ppm NO2 for intervals ranging from 1 to 8 wk. Emphysema development was assessed by histologic evaluation and by changes in lung volume and mean linear intercept values. Evidence of pathologic changes were also documented by clinical and radiographic findings of osteolathyrism. The induction of centriacinar emphysema was attributed specifically to NO2 exposure. Neither the severity of the emphysema nor the time course of its development was altered by the beta APN-supplemented diet. These findings are in marked contrast to those observed with the exogenous elastase model of the disease, and they suggest that elastin synthesis and repair may not modulate elastin destruction in the NO2 model of emphysema.
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
May 1967,
The American review of respiratory disease,
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
February 1967,
Experimental and molecular pathology,
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
March 1957,
Science (New York, N.Y.),
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
January 1994,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
April 1960,
Archives of pathology,
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
January 1995,
Acta physiologica Hungarica,
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
January 1970,
Toxicology and applied pharmacology,
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
November 1982,
The American review of respiratory disease,
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
December 1985,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
J Blank, and
J E Glasgow, and
G G Pietra, and
L Burdette, and
G Weinbaum
March 1966,
Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan,
