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The bile acid-binding resin cholestyramine was administered in a dose of 4 g every six hours to a patient with digoxin intoxication. The serum digoxin concentration declined rapidly, and the digoxin half-life decreased from 75.5 hours to 19.9 hours while cholestyramine was administered. All signs and symptoms of toxic reaction subsided during the period of cholestyramine therapy, which correlated with the decline in digoxin concentrations. Cholestyramine and a related agent, colestipol, presumably interrupt the enterohepatic recycling of digoxin to enhance elimination. These agents represent potentially useful adjunctive measures in the management of non-life-threatening digitalis intoxication.
R P Henderson, and
C P Solomon
March 1979,
Schweizerische medizinische Wochenschrift,
R P Henderson, and
C P Solomon
August 1977,
British medical journal,
R P Henderson, and
C P Solomon
March 1973,
Lancet (London, England),
R P Henderson, and
C P Solomon
July 1973,
Lancet (London, England),
R P Henderson, and
C P Solomon
April 1986,
Drug intelligence & clinical pharmacy,
R P Henderson, and
C P Solomon
October 1986,
Clinical pharmacy,
R P Henderson, and
C P Solomon
June 1974,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
R P Henderson, and
C P Solomon
October 1982,
Southern medical journal,
R P Henderson, and
C P Solomon
January 1993,
Pharmacology & toxicology,
