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Diphenylhydantoin is one of the most widely used anticonvulsant agents in humans. To examine its effects on brain metabolism, we used the quantitative autoradiographic [14C]deoxyglucose method to measure local cerebral glucose utilization in adult rats receiving 50 mg/kg/day diphenylhydantoin for 1 week. Thirty-three brain structures were analyzed to determine whether the drug has global or site-specific effects on cerebral metabolism. Chronic administration produced statistically significant decreases in 23 neocortical and subcortical structures compared with those in vehicle-injected control animals. Therefore, our data support the concept that diphenylhydantoin has widespread depressant effects on brain metabolism.
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
January 1976,
Biochemical pharmacology,
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
January 1970,
The Journal of pharmacology and experimental therapeutics,
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
December 1995,
Neurology,
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
January 1971,
The Journal of pharmacology and experimental therapeutics,
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
February 1974,
Science (New York, N.Y.),
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
August 1980,
Neurochemical research,
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
April 1978,
Canadian journal of physiology and pharmacology,
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
January 1980,
Psychopharmacology,
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
December 1992,
Biochimica et biophysica acta,
J W Melisi, and
D L Dow-Edwards, and
M K Hammock, and
T H Milhorat
January 1965,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
