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Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA. 2021
Zheng Wang, and
Lijun Wen, and
Ling Zhang, and
Xiaoyu Xu, and
Xiaoqian Chen, and
Li Yao, and
Man Wang, and
Zhen Shen, and
Guangquan Mo, and
Yao Wang, and
Dewan Zhao, and
Wei Cai, and
Jingzhi Shen, and
Xiaomeng Chi, and
Yi Xu, and
Zhao Zeng, and
Jinlan Pan, and
Changgeng Ruan, and
Depei Wu, and
Zhilin Jia, and
Suning Chen
National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, P.R. China.
Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML-RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18-RARA as novel RARA fusion in resembling APL. Our study highlights the importance of combining multiple molecular techniques to characterize and optimally manage APL lacking classic t(15;17)(q24;q12)/PML-RARA fusion.
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