Biomaterial Database

Development of a potentially reversible vas deferens occlusion device and evaluation in primates. 1988

L J Zaneveld, and J W Burns, and S Beyler, and W Depel, and S Shapiro

Department of Obstetrics and Gynecology, Rush-Presbyterian-St. Luke's Medical Center, University of Illinois at Chicago 60612-3864.

A vas deferens occlusion device has been developed and tested in primates. The device consists of two silicone plugs held together by a nylon suture. Implantation of each plug is readily accomplished by making two small puncture holes in the vas deferens and inserting one plug into the lumen toward the epididymis and the other plug toward the seminal vesicles. Implantation is aided by a metal stylus inserted in each plug to give the plug rigidity. The stylus is removed after insertion of the plug into the vas deferens. Two separate primate experiments showed that the device completely prevents sperm transport over a 7-month period. Upon device removal, all of the primates ejaculated spermatozoa again at normal concentrations and motility. These results indicate the potential contraceptive use of the device and encourage its validation in men.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013245	Sterilization, Reproductive	Procedures to block or remove all or part of the genital tract for the purpose of rendering individuals sterile, incapable of reproduction. Surgical sterilization procedures are the most commonly used. There are also sterilization procedures involving chemical or physical means.	Reproductive Sterilization,Voluntary Sterilization,Female Sterilization,Female Sterilization, Voluntary,Male Sterilization,Male Sterilization, Voluntary,Female Sterilizations,Female Sterilizations, Voluntary,Male Sterilizations,Male Sterilizations, Voluntary,Reproductive Sterilizations,Sterilization, Female,Sterilization, Male,Sterilization, Voluntary,Sterilizations, Female,Sterilizations, Male,Sterilizations, Reproductive,Sterilizations, Voluntary,Voluntary Female Sterilization,Voluntary Female Sterilizations,Voluntary Male Sterilization,Voluntary Male Sterilizations,Voluntary Sterilizations
D014649	Vas Deferens	The excretory duct of the testes that carries SPERMATOZOA. It rises from the SCROTUM and joins the SEMINAL VESICLES to form the ejaculatory duct.	Ductus Deferens,Deferens, Ductus,Deferens, Vas