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Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials. 2021
Fernando Gordillo Altamirano, and
John H Forsyth, and
Ruzeen Patwa, and
Xenia Kostoulias, and
Michael Trim, and
Dinesh Subedi, and
Stuart K Archer, and
Faye C Morris, and
Cody Oliveira, and
Luisa Kielty, and
Denis Korneev, and
Moira K O'Bryan, and
Trevor J Lithgow, and
Anton Y Peleg, and
Jeremy J Barr
School of Biological Sciences, Monash University, Clayton, Victoria, Australia. fernando.gordilloaltamirano@monash.edu.
We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii and established that the bacterial capsule is the receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible for capsule biosynthesis, resulting in capsule loss and disruption of phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam antibiotics and alternative phages and exhibited diminished fitness in vivo. Using a mouse model of A. baumannii infection, we showed that phage therapy was effective.
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