Biomaterial Database

Physical and hydrodynamic factors affecting erythrocyte adhesion to polymer surfaces. 1988

G Chang, and D R Absolom, and A B Strong, and G D Stubley, and W Zingg

Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

Using a flow cell design which ensures fully developed laminar flow, the influence of various hydrodynamic and physical factors in determining the extent of erythrocyte adhesion to various polymer surfaces has been examined. Specifically we have investigated the effect of exposure time, flow rate, erythrocyte concentration, and substrate surface tension on the extent of erythrocyte adhesion. The results indicate: (1) the extent of erythrocyte adhesion is most extensive on the more hydrophobic surfaces; (2) the rate of adhesion is higher on the more hydrophobic surfaces; (3) saturation coverage occurs after 7-10 min of exposure to the erythrocyte suspension for all substrates examined. No "lag-time" in the onset of adhesion was observed; (4) The level of saturation depends on the bulk erythrocyte concentration, increasing with increasing cell concentration; (5) the extent of adhesion decreases with an increase in flow rate; and (6) substrate surface defects such as roughness have a major effect on the pattern of erythrocyte adhesion.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008297	Male		Males
D011108	Polymers	Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).	Polymer
D002448	Cell Adhesion	Adherence of cells to surfaces or to other cells.	Adhesion, Cell,Adhesions, Cell,Cell Adhesions
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001672	Biocompatible Materials	Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.	Biomaterials,Bioartificial Materials,Hemocompatible Materials,Bioartificial Material,Biocompatible Material,Biomaterial,Hemocompatible Material,Material, Bioartificial,Material, Biocompatible,Material, Hemocompatible
D013500	Surface Tension	The force acting on the surface of a liquid, tending to minimize the area of the surface. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Interfacial Force,Interfacial Tension,Surface Tensions,Tension, Surface,Tensions, Surface