Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor. 2021

Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
Department of Physiology, National University of Singapore, Singapore City, Singapore.

The plasticity mechanisms in the nervous system that are important for learning and memory are greatly impacted during aging. Notably, hippocampal-dependent long-term plasticity and its associative plasticity, such as synaptic tagging and capture (STC), show considerable age-related decline. The p75 neurotrophin receptor (p75NTR ) is a negative regulator of structural and functional plasticity in the brain and thus represents a potential candidate to mediate age-related alterations. However, the mechanisms by which p75NTR affects synaptic plasticity of aged neuronal networks and ultimately contribute to deficits in cognitive function have not been well characterized. Here, we report that mutant mice lacking the p75NTR were resistant to age-associated changes in long-term plasticity, associative plasticity, and associative memory. Our study shows that p75NTR is responsible for age-dependent disruption of hippocampal homeostatic plasticity by modulating several signaling pathways, including BDNF, MAPK, Arc, and RhoA-ROCK2-LIMK1-cofilin. p75NTR may thus represent an important therapeutic target for limiting the age-related memory and cognitive function deficits.

UI MeSH Term Description Entries
D008297 Male Males
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009473 Neuronal Plasticity The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations. Brain Plasticity,Plasticity, Neuronal,Axon Pruning,Axonal Pruning,Dendrite Arborization,Dendrite Pruning,Dendritic Arborization,Dendritic Pruning,Dendritic Remodeling,Neural Plasticity,Neurite Pruning,Neuronal Arborization,Neuronal Network Remodeling,Neuronal Pruning,Neuronal Remodeling,Neuroplasticity,Synaptic Plasticity,Synaptic Pruning,Arborization, Dendrite,Arborization, Dendritic,Arborization, Neuronal,Arborizations, Dendrite,Arborizations, Dendritic,Arborizations, Neuronal,Axon Prunings,Axonal Prunings,Brain Plasticities,Dendrite Arborizations,Dendrite Prunings,Dendritic Arborizations,Dendritic Prunings,Dendritic Remodelings,Network Remodeling, Neuronal,Network Remodelings, Neuronal,Neural Plasticities,Neurite Prunings,Neuronal Arborizations,Neuronal Network Remodelings,Neuronal Plasticities,Neuronal Prunings,Neuronal Remodelings,Neuroplasticities,Plasticities, Brain,Plasticities, Neural,Plasticities, Neuronal,Plasticities, Synaptic,Plasticity, Brain,Plasticity, Neural,Plasticity, Synaptic,Pruning, Axon,Pruning, Axonal,Pruning, Dendrite,Pruning, Dendritic,Pruning, Neurite,Pruning, Neuronal,Pruning, Synaptic,Prunings, Axon,Prunings, Axonal,Prunings, Dendrite,Prunings, Dendritic,Prunings, Neurite,Prunings, Neuronal,Prunings, Synaptic,Remodeling, Dendritic,Remodeling, Neuronal,Remodeling, Neuronal Network,Remodelings, Dendritic,Remodelings, Neuronal,Remodelings, Neuronal Network,Synaptic Plasticities,Synaptic Prunings
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017475 Receptors, Nerve Growth Factor Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR. NGF Receptors,Nerve Growth Factor Receptors,Neurotrophic Factor Receptor,Neurotrophin Receptor,Receptors, NGF,Receptors, Neurotrophin,Neurotrophin Receptors,Receptors, Neurotrophic Factor,Neurotrophic Factor Receptors,Receptor, Neurotrophic Factor,Receptor, Neurotrophin
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018345 Mice, Knockout Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes. Knockout Mice,Mice, Knock-out,Mouse, Knockout,Knock-out Mice,Knockout Mouse,Mice, Knock out

Related Publications

Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
July 2019, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
November 1999, Brain research. Brain research reviews,
Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
January 1988, Neurobiology of aging,
Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
September 2008, The European journal of neuroscience,
Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
April 2010, Journal of dermatological science,
Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
October 2014, The Journal of clinical investigation,
Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
November 2009, Anesthesiology,
Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
January 2010, Hippocampus,
Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
February 2011, Proceedings of the National Academy of Sciences of the United States of America,
Lik-Wei Wong, and Yee Song Chong, and Wei Lin, and Lilian Kisiswa, and Eunice Sim, and Carlos F Ibáñez, and Sreedharan Sajikumar
April 2008, Behavioral neuroscience,
Copied contents to your clipboard!