-transparent.png){kind=logo}
The purpose of this study was to provide new evidence favoring the hypothesis that cardiovascular information from arterial baroreceptors is integrated with the nigrostriatal system that contributes to regulation of motor activity. Samples of extracellular striatal dopamine (DA) and its metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), were collected by the technique of in vivo microdialysis and analyzed by high-performance liquid chromatography-electron capture detection. Rats were prepared with a guide tube placed in the caudate-putamen for subsequent insertion of microdialysis probes. During the 1st wk after sinoaortic denervation (SAD) or sham operation (SO), a microdialysis probe was inserted and perfused with Ringer solution at the rate of 2 microliter/min in the freely moving rats. Samples were collected every 20 min before and after injection of pargyline, 100 mg/kg ip. The results showed that SAD rats have approximately 50% less extracellular striatal DA, DOPAC, and HVA than SO rats (P less than 0.01). After blockade of monoamine oxidase activity with pargyline, striatal DA accumulated three times faster in SO than SAD rats suggesting DA synthesis is reduced in SAD rats. These data provide further evidence that the arterial baroreceptor system affects dopaminergic metabolism in the nigrostriatal system possibly as a means for integration of cardiovascular and motor activity.
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
November 1988,
Brain research,
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
April 1998,
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
July 2006,
Mechanisms of ageing and development,
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
March 1989,
Neuroscience letters,
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
August 1991,
Journal of neurochemistry,
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
December 1980,
Clinical science (London, England : 1979),
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
December 1987,
Neuroscience letters,
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
November 1991,
Pharmacology, biochemistry, and behavior,
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
January 1990,
Brain research,
N Alexander, and
D Nakahara, and
N Ozaki, and
N Kaneda, and
T Sasaoka, and
N Iwata, and
T Nagatsu
March 1998,
British journal of pharmacology,
