A proliferation of empirical studies over the past few decades has examined the connection between religiosity and health; an extension of this literature has focused on the association between three styles of religious problem-solving-collaborative, self-directing and deferring-and psychological adjustment. Few studies, however, have examined variables that may mediate this association. The present study utilized a cross-sectional design to examine the pathways (means to attain goals) and agency (goal-directed energy and determination) components of hope as mediators in the association between religious problem-solving styles and psychosocial adjustment. Students (n = 91) at a midsize Southeastern university completed a demographic questionnaire, the Religious Problem-solving Styles Scale, Adult Hope Scale, and the Life Satisfaction Scale. Mediation analyses revealed that both the collaborative and deferring religious problem-solving styles were positively associated with life satisfaction through agency thinking, but the self-directing religious problem-solving style was negatively associated with life satisfaction through agency thinking. Contrary to expectations, there was no significant indirect effect of any of the religious problem-solving styles on life satisfaction via pathways thinking. These results suggest that approaching problems within a specific religious framework is associated with psychosocial adjustment, and that each religious problem-solving style may exert its effects by either amplifying or quelling goal-directed motivation and willpower. Future studies should utilize quasi-experimental designs in order to delineate cause-and-effect relationships among religious problem-solving styles, agency and pathways thinking, and psychosocial adjustment.