-transparent.png){kind=logo}
The clinical effects and plasma levels associated with the use of 0.5% bupivacaine with and without the addition of 1:200,000 adrenaline (5 micrograms/ml) were studied in 30 patients who underwent extradural anaesthesia for elective Caesarean section. The addition of adrenaline to bupivacaine prolongs analgesia, reduces the degree of hypotension and delays its onset. Plasma bupivacaine levels were consistently lower when adrenaline was added, but this difference was significant only at 10 minutes after the initial dose. Prolonging the interval between increments seems to be a more reliable way to reduce plasma concentration than the addition of the catecholamine.
Related Publications
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
February 1988,
British journal of anaesthesia,
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
December 1991,
British journal of anaesthesia,
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
October 1995,
International journal of obstetric anesthesia,
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
June 1991,
British journal of anaesthesia,
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
December 1992,
British journal of anaesthesia,
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
December 1991,
British journal of anaesthesia,
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
August 1988,
British journal of anaesthesia,
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
September 1993,
British journal of anaesthesia,
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
March 1990,
British journal of anaesthesia,
C M Wilson, and
J Moore, and
R G Ghaly, and
R Flynn, and
E McClean, and
J W Dundee
November 1992,
Anaesthesia,
