-transparent.png){kind=logo}
The brown pigment found in the black thyroid, associated with minocycline therapy, was studied histochemically and ultrastructurally. The brown pigment was Fontana-Masson silver-positive, and was negative for iron, for autofluorescence under uv illumination, for periodic acid Schiff (PAS) and for acid-fast iodine peroxidase (AFIP) lipofuscin, and was bleached with potassium permanganate. The light and electron microscopic studies suggested that the pigment resembled melanin. Although the mechanism of the pigment deposition is not clear, a possible explanation may be that the pigment is related to direct oxidative degradation products of minocycline.
Related Publications
M Senba, and
Y Toda, and
H Yamashita
January 1989,
Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie,
M Senba, and
Y Toda, and
H Yamashita
April 1984,
Archives of pathology & laboratory medicine,
M Senba, and
Y Toda, and
H Yamashita
June 1983,
The Medical journal of Australia,
M Senba, and
Y Toda, and
H Yamashita
April 1992,
Medicine, science, and the law,
M Senba, and
Y Toda, and
H Yamashita
January 2001,
Endocrine pathology,
M Senba, and
Y Toda, and
H Yamashita
May 1995,
Archives of dermatology,
M Senba, and
Y Toda, and
H Yamashita
March 2000,
Applied immunohistochemistry & molecular morphology : AIMM,
M Senba, and
Y Toda, and
H Yamashita
January 1996,
Endocrine pathology,
M Senba, and
Y Toda, and
H Yamashita
June 2022,
QJM : monthly journal of the Association of Physicians,
