BIOMAT Database Logo BIOMAT Database Logo

Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System. 2021

Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, Negeri Sembilan, Malaysia.

The synthesis and secretion of cortisol are controlled by the hypothalamic-pituitary-adrenal axis. Cortisol exhibits a proper 24-h circadian rhythm that affects the brain, the autonomic nervous system, the heart, and the vasculature that prepares the cardiovascular system for optimal function during these anticipated behavioral cycles. A literature search was conducted using databases such as Google Scholar, PubMed, and Scopus. Relevant search terms included "circadian rhythm and cardiovascular", "cortisol", "cortisol and acute coronary syndrome", "cortisol and arrhythmias", "cortisol and sudden cardiac death", "cortisol and stroke", and "cardioprotective agents". A total of 120 articles were obtained on the basis of the above search. Lower levels of cortisol were seen at the beginning of sleep, while there was a rise towards the end of sleep, with the highest level reached at the moment the individual wakes up. In the present review, we discuss the role of 11β-hydroxysteroid dehydrogenase (11β-HSD1), which is a novel molecular target of interest for treating metabolic syndrome and type-2 diabetes mellitus. 11β-HSD1 is the major determinant of cortisol excess, and its inhibition alleviates metabolic abnormalities. The present review highlights the role of cortisol, which controls the circadian rhythm, and describes its effect on the cardiovascular system. The review provides a platform for future potential cardioprotective therapeutic agents.

UI MeSH Term Description Entries
D007030 Hypothalamo-Hypophyseal System A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS. Hypothalamic Hypophyseal System,Hypothalamo-Pituitary-Adrenal Axis,Hypophyseal Portal System,Hypothalamic-Pituitary Unit,Hypothalamic Hypophyseal Systems,Hypothalamic Pituitary Unit,Hypothalamo Hypophyseal System,Hypothalamo Pituitary Adrenal Axis,Portal System, Hypophyseal
D010913 Pituitary-Adrenal System The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary. Pituitary Adrenal System,Pituitary-Adrenal Systems,System, Pituitary-Adrenal,Systems, Pituitary-Adrenal
D002319 Cardiovascular System The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body. Circulatory System,Cardiovascular Systems,Circulatory Systems
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D006854 Hydrocortisone The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D043205 11-beta-Hydroxysteroid Dehydrogenase Type 1 A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors. 11 beta-Hydroxysteroid Dehydrogenase Type 1,11beta-HSD1,11beta-HSD1 Reductase,11beta-Hydroxysteroid Dehydrogenase Type 1,11beta HSD1 Reductase,11beta Hydroxysteroid Dehydrogenase Type 1

Related Publications

Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
[Circadian rhythm of cardiovascular system morbidity].
September 1981, Polski tygodnik lekarski (Warsaw, Poland : 1960),
Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
Effect of confinement on the circadian rhythm of ovine cortisol.
April 1975, The Journal of endocrinology,
Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
Effect of transportation on cortisol concentrations and on the circadian rhythm of cortisol in gilts.
July 1985, American journal of veterinary research,
Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
Circadian rhythm in the cardiovascular system: chronocardiology.
May 2003, American heart journal,
Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
Effect of recovery on the cortisol circadian rhythm of depressed patients.
July 1988, Biological psychiatry,
Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
Effect of night-shift work on cortisol circadian rhythm and melatonin levels.
January 2022, Sleep science (Sao Paulo, Brazil),
Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
[Circadian rhythm in cortisol secretion].
June 1979, Nihon rinsho. Japanese journal of clinical medicine,
Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
[Circadian rhythm of cortisol and its responsiveness to ACTH during Ramadan].
December 2002, Annales d'endocrinologie,
Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
Circadian rhythm and cardiovascular disease.
July 2009, Current atherosclerosis reports,
Nor Amira Syahira Mohd Azmi, and Norsham Juliana, and Sahar Azmani, and Nadia Mohd Effendy, and Izuddin Fahmy Abu, and Nur Islami Mohd Fahmi Teng, and Srijit Das
[Effect of cyproheptadine treatment on the human circadian rhythm of ACTH and plasma cortisol].
November 1977, Bollettino della Societa italiana di biologia sperimentale,
Copied contents to your clipboard!