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A rapid method was developed for the determination of diazepam and nordiazepam (N-desmethyldiazepam) in human plasma using electron capture gas--liquid chromatography (GLC--ECE). The concentration of diazepam and nordiazepam is determined using 0.5 ml of plasma extracted with 1.0 ml of benzene containing 25 ng/ml of methylnitrazepam as the internal standard. The benzene extract is removed and an aliquot is subjected to automated GLC-ECD analysis. The method has a sensitivity limit of 5 ng diazepam and 10ng nordiazepam per milliliter of plasma. The method was used to determine the plasma levels in man following the first 5-mg diazepam dose, as well as during chronic oral administration of 5 mg diazepam three times daily and 15 mg diazepam once a day.
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
July 1979,
Clinical chemistry,
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
July 1977,
Clinical chemistry,
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
November 2000,
Se pu = Chinese journal of chromatography,
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
October 1971,
Journal of chromatography,
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
July 1972,
Journal of chromatography,
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
October 1980,
Journal of chromatography,
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
June 1975,
Journal of chromatography,
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
January 1980,
Journal de pharmacie de Belgique,
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
September 1977,
Clinical chemistry,
R E Weinfeld, and
H N Posmanter, and
K C Khoo, and
C V Puglisi
December 1982,
Journal of chromatography,
