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Alkylacylglycerols are synthesized when choline-phospholipids are degraded by a phospholipase C. This class of compounds has been shown to have biological activities; however, the mechanism of action is unknown. A series of alkyl-linked diglycerides were synthesized and tested for activity in an in vitro assay for protein kinase C. When protein kinase C activity was stimulated with the synthetic diacylglyceride analog 1-oleoyl-2-acetyl-sn-glycerol, the addition of alkyl glycerides caused a concentration-dependent inhibition of protein kinase C activity. Comparison of the protein kinase C inhibition by this series of 1-O-alkyl-2-acyl analogs revealed that both saturated and unsaturated long-chain groups in position 1 were effective and that dietherglycerols with short-chain moieties in position 2 were also effective. It is concluded from these studies that the biological activity of alkyl-linked glycerides may be expressed through protein kinase C inhibition.
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J D Schmitt, and
C J Marasco, and
K Ishaq, and
C Piantadosi
August 1989,
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L W Daniel, and
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C Piantadosi
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L W Daniel, and
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L W Daniel, and
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L W Daniel, and
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L W Daniel, and
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L W Daniel, and
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C J Marasco, and
K Ishaq, and
C Piantadosi
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Lipids,
