Biomaterial Database

Enhancement of lectin-induced cap formation in human neutrophils by cyclosporin A. 1988

P Soon-Shiong, and I S Grewal

Department of Surgery, UCLA Medical Center.

Cyclosporin A, a potent immunosuppressive agent, has been extensively studied for its immunomodulatory effects on T-cells. Recently Cyclosporin A has been shown to cause renal damage, which correlates with increased glomerular neutrophil migration. The precise role of Cyclosporin A on neutrophil function has not been established. In this study we investigated the role of Cyclosporin A in the regulation of cap formation in human neutrophils. Our results show an increased concanavalin A-induced cap formation in human neutrophils pretreated with Cyclosporin A, implicating a possible role of Cyclosporin A in human neutrophil activation. The correlation between enhanced capping, renal nephrotoxicity and neutrophil migration remains to be studied.

UI	MeSH Term	Description	Entries
D007152	Immunologic Capping	An energy dependent process following the crosslinking of B CELL ANTIGEN RECEPTORS by multivalent ligands (bivalent anti-antibodies, LECTINS or ANTIGENS), on the B-cell surface. The crosslinked ligand-antigen receptor complexes collect in patches which flow to and aggregate at one pole of the cell to form a large mass - the cap. The caps may then be endocytosed or shed into the environment.	Capping, Immunologic,Immunological Capping,Capping, Immunological
D009504	Neutrophils	Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.	LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D003208	Concanavalin A	A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
D003524	Cyclosporins	A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.	Cyclosporines
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man