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The effect of endotoxin on the colon glutathione level was studied in male rats. Endotoxin (Escherichia coli) from 25 ug to 100 ug/100g body weight was administered intravenously. The Glutathione level was measured 16 hours after endotoxin was given. Results showed that endotoxin significantly enhanced the colon glutathione concentration as measured by 5,5'-dithiobis (2-nitrobenzoic acid). The increase which ranged from 11% to 50% was dose dependent. At an endotoxin dose of 1000 ug/100g body weight, colon glutathione level was found to be enhanced from 2 hours up to 48 hours. In contrast, the duodenum and jejunum glutathione levels were found to be significantly reduced. The increase in the colon glutathione level may have a protective effect against oxidative damage to the colon.
M F Chen, and
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H W Boyce
January 1983,
Acta vitaminologica et enzymologica,
M F Chen, and
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H W Boyce
October 1983,
Masui. The Japanese journal of anesthesiology,
M F Chen, and
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H W Boyce
December 1968,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M F Chen, and
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January 1983,
Biomedica biochimica acta,
M F Chen, and
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Strahlentherapie,
M F Chen, and
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The Journal of nutrition,
M F Chen, and
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Doklady. Biochemistry and biophysics,
M F Chen, and
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January 1967,
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M F Chen, and
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H W Boyce
January 1967,
Acta microbiologica Academiae Scientiarum Hungaricae,
M F Chen, and
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H W Boyce
January 1974,
Journal of biochemistry,
