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Soluble extracts from human lymphoid cell lines that perform repair synthesis on covalently closed circular DNA containing pyrimidine dimers or psoralen adducts are described. Short patches of nucleotides are introduced by excision repair of damaged DNA in an ATP-dependent reaction. Extracts from xeroderma pigmentosum cell lines fail to act on damaged circular DNA, but are proficient in repair synthesis of ultraviolet-irradiated DNA containing incisions generated by Micrococcus luteus pyrimidine dimer-DNA glycosylase. Repair is defective in extracts from all xeroderma pigmentosum cell lines investigated, representing the genetic complementation groups A, B, C, D, H, and V. Mixing of cell extracts of group A and C origin leads to reconstitution of the DNA repair activity.
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March 1989,
Gan to kagaku ryoho. Cancer & chemotherapy,
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January 1990,
Nucleic acids research,
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June 1984,
Carcinogenesis,
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Proceedings of the National Academy of Sciences of the United States of America,
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January 1983,
The EMBO journal,
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April 1984,
The Journal of investigative dermatology,
R D Wood, and
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Basic life sciences,
