Biomaterial Database

Isobutyl cyanoacrylate as a soft tissue adhesive. An in vitro study in the rabbit Achilles tendon. 1988

P M Bonutti, and G G Weiker, and J T Andrish

Department of Orthopaedics, Cleveland Clinic Foundation, Ohio.

Cyanoacrylates (CAs) are biodegradable, bacteriostatic, and hemostatic adhesives. CAs have been used in medical applications, but with adverse effects, including excessive inflammatory reaction and neural toxicity. Isobutyl CA (ICA) appears more biocompatible, with a long half-life that may be ideal for a soft tissue adhesive. The rabbit Achilles tendon was chosen to test (ICA), and a special muscle-freezing clamp to test this model was designed. The tendons were sharply cut 2 cm proximal to their insertion and repaired in four groups. They were tested to failure on an Instron machine. The breaking strength of the repairs was then noted. Also, the breaking strength of several suture materials was tested. Four Achilles tendon repair groups were evaluated: ICA alone 9.03 newtons (NTS); 4-0 silk Kessler stitch, mean 12.9 NTS; Kessler stitch plus three simple stitches, mean 23.0 NTS; and a combination of (a) and (c)--i.e., suture and adhesive, mean 40.2 NTS. The intact Achilles tendon was tested with an average breaking strength of 317 NTS. The muscle-freezing clamp facilitated reasonable testing of this tendon repair. ICA alone exhibits reasonable strength in vitro and in combination with suture provides a stronger initial repair than either suture or adhesive alone.

UI	MeSH Term	Description	Entries
D008422	Materials Testing	The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.	Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002015	Bucrylate	Cyanoacrylate tissue adhesive also used to occlude blood vessels supplying neoplastic or other diseased tissue.	Isobutylcyanoacrylate,Bucrilate,Isobutyl Cyanoacrylate,Isobutyl alpha-Cyanoacrylate,Isobutyl-2-cyanoacrylate,Cyanoacrylate, Isobutyl,Isobutyl 2 cyanoacrylate,Isobutyl alpha Cyanoacrylate,alpha-Cyanoacrylate, Isobutyl
D003487	Cyanoacrylates	A group of compounds having the general formula CH2	Cyanoacrylate
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D000125	Achilles Tendon	Tendon that connects the muscles in the back of the calf to the HEEL BONE.	Calcaneal Tendon,Tendo Calcaneus,Calcaneal Tendons,Tendon, Achilles,Tendon, Calcaneal,Tendons, Calcaneal
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013314	Stress, Mechanical	A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.	Mechanical Stress,Mechanical Stresses,Stresses, Mechanical
D013537	Sutures	Materials used in closing a surgical or traumatic wound. (From Dorland, 28th ed)	Staples, Surgical,Surgical Staples,Staple, Surgical,Surgical Staple,Suture
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In