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Multi-organ proteomic landscape of COVID-19 autopsies. 2021
Xiu Nie, and
Liujia Qian, and
Rui Sun, and
Bo Huang, and
Xiaochuan Dong, and
Qi Xiao, and
Qiushi Zhang, and
Tian Lu, and
Liang Yue, and
Shuo Chen, and
Xiang Li, and
Yaoting Sun, and
Lu Li, and
Luang Xu, and
Yan Li, and
Ming Yang, and
Zhangzhi Xue, and
Shuang Liang, and
Xuan Ding, and
Chunhui Yuan, and
Li Peng, and
Wei Liu, and
Xiao Yi, and
Mengge Lyu, and
Guixiang Xiao, and
Xia Xu, and
Weigang Ge, and
Jiale He, and
Jun Fan, and
Junhua Wu, and
Meng Luo, and
Xiaona Chang, and
Huaxiong Pan, and
Xue Cai, and
Junjie Zhou, and
Jing Yu, and
Huanhuan Gao, and
Mingxing Xie, and
Sihua Wang, and
Guan Ruan, and
Hao Chen, and
Hua Su, and
Heng Mei, and
Danju Luo, and
Dashi Zhao, and
Fei Xu, and
Yan Li, and
Yi Zhu, and
Jiahong Xia, and
Yu Hu, and
Tiannan Guo
Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report a proteomic analysis of 144 autopsy samples from seven organs in 19 COVID-19 patients. We quantified 11,394 proteins in these samples, in which 5,336 were perturbed in the COVID-19 patients compared to controls. Our data showed that cathepsin L1, rather than ACE2, was significantly upregulated in the lung from the COVID-19 patients. Systemic hyperinflammation and dysregulation of glucose and fatty acid metabolism were detected in multiple organs. We also observed dysregulation of key factors involved in hypoxia, angiogenesis, blood coagulation, and fibrosis in multiple organs from the COVID-19 patients. Evidence for testicular injuries includes reduced Leydig cells, suppressed cholesterol biosynthesis, and sperm mobility. In summary, this study depicts a multi-organ proteomic landscape of COVID-19 autopsies that furthers our understanding of the biological basis of COVID-19 pathology.
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