-transparent.png){kind=logo}
The number of dendritic spines on the apical dendrites of layer III pyramidal cells was counted in cerebral biopsies, processed in part according to the rapid Golgi method, which had been performed for diagnostic purposes on patients suffering from dementia of different origins. The samples were from cases affected by Alzheimer's disease (3 patients), Parkinson's disease and dementia (1 patient), Creutzfeldt-Jacob disease (4 patients), Pick's disease (1 patient) and dementia paralytica (1 patient). Spines were counted on consecutive segments of the apical dendrite along the 500-microns proximal region from the cell body. A significant decrease in the number of spines was observed in almost every segment of the apical dendrite in demented patients when compared with similar measurements carried out in age-matched controls (p less than 0.01-0.001); Mann-Whitney U-test. Decreased numbers of dendritic spines may result in reduced inputs on cortical neurons and may be a consistent morphological substrate for the impaired mental status in cortical dementia.
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
August 1986,
Neuroscience letters,
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
January 2016,
eNeuro,
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
November 2013,
Brain structure & function,
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
October 1993,
Neurology,
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
January 2000,
Archives of general psychiatry,
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
January 1995,
Developmental neuroscience,
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
July 1987,
Rinsho shinkeigaku = Clinical neurology,
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
October 1995,
Brain research,
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
January 1987,
Journal fur Hirnforschung,
I Catalá, and
I Ferrer, and
E Galofré, and
I Fábregues
January 2014,
Frontiers in neuroanatomy,
