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We report measurements of absorbed dose to vertebral metastases in ten patients referred for 89Sr therapy for disseminated prostatic carcinoma. Patients received a tracer dose of 85Sr at the time of 89Sr treatment and metastatic strontium retention was monitored scintigraphically for 6 mo. Metastatic 85Sr activity corrected for tissue attenuation was measured using the conjugate view principle, with special care taken to eliminate errors due to the selection of the metastatic region of interest. Metastatic volume was determined from high resolution CT images, and density inferred from Hounsfield number using the QCT bone mineral calibration of Genant and Cann. The mean absorbed dose was 850 rad/mCi (23 cGy/MBq) with a range from 220-2260 rad/mCi (6 to 61 cGy/MBq). The wide range found was consistent with the variation expected to arise due to differences in strontium renal plasma clearance (range 0.1-11.81/day) and extent of skeletal metastatic disease (varying from two small metastases to a superscan on [99mTc]MDP images) among the patients studied.
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
January 2004,
Voprosy onkologii,
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
June 1995,
Nuclear medicine communications,
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
February 1994,
Oncology (Williston Park, N.Y.),
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
April 1985,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
January 1988,
European journal of nuclear medicine,
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
August 1995,
JAMA,
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
May 1995,
Harefuah,
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
September 1997,
Clinical nuclear medicine,
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
January 1986,
Journal of the National Medical Association,
G M Blake, and
M A Zivanovic, and
R M Blaquiere, and
D R Fine, and
A J McEwan, and
D M Ackery
January 1998,
The American journal of hospice & palliative care,
