Beta-substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine beta-hydroxylase. 1988

L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
Department of Medicinal Chemistry, Smith Kline & French Laboratories, Swedeland, Pennsylvania 19406.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D007700 Kinetics The rate dynamics in chemical or physical systems.
D010627 Phenethylamines A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed) Phenylethylamines
D011918 Rats, Inbred SHR A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. Rats, Spontaneously Hypertensive,Rats, SHR,Inbred SHR Rat,Inbred SHR Rats,Rat, Inbred SHR,Rat, SHR,Rat, Spontaneously Hypertensive,SHR Rat,SHR Rat, Inbred,SHR Rats,SHR Rats, Inbred,Spontaneously Hypertensive Rat,Spontaneously Hypertensive Rats
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D004299 Dopamine beta-Hydroxylase Dopamine beta-Monooxygenase,Dopamine beta Hydroxylase,Dopamine beta Monooxygenase,beta-Hydroxylase, Dopamine,beta-Monooxygenase, Dopamine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

Related Publications

L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
April 1989, Journal of medicinal chemistry,
L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
September 1987, Archives of biochemistry and biophysics,
L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
January 1982, Biochemistry,
L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
April 1985, Biochemistry,
L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
June 1984, The Journal of biological chemistry,
L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
May 1983, Die Pharmazie,
L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
January 1990, Journal of medicinal chemistry,
L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
January 1979, Die Pharmazie,
L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
December 1984, The Journal of biological chemistry,
L I Kruse, and C Kaiser, and W E DeWolf, and P A Chambers, and P J Goodhart, and M Ezekiel, and E H Ohlstein
January 1976, Advances in enzyme regulation,
Copied contents to your clipboard!