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Injectable thermosensitive hydrogel-based drug delivery system for local cancer therapy. 2021
Yin Xiao, and
Yuhong Gu, and
Li Qin, and
Lin Chen, and
Xiaoliang Chen, and
Weiheng Cui, and
Fuling Li, and
Ni Xiang, and
Xiaoai He
Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570100, China. Electronic address: xxyy_614@163.com.
Injectable thermosensitive hydrogel has been regarded as attractive drug delivery system, which displays a sol-gel phase transition upon injection in response to temperature. Recently, thermosensitive hydrogel has become a matter of importance in cancer therapy, providing high local drug concentration, sustained release characteristics, minimal invasiveness, and low systemic toxicities. Here, we review the extensive application of thermosensitive hydrogel in local cancer therapy, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, chemo-photothermal combined therapy, and chemo-/immuno- combined therapy.
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