Biomaterial Database

[Fractionated irradiation of Ehrlich carcinoma using fast neutrons]. 1988

S A Averin, and V N Letov

Ehrlich's carcinoma growth inhibition was studied under the conditions of fractionated irradiation with fast neutrons and x-rays. Fast neutrons were obtained from a reaction of 13.6 MeV alpha----Be on the Y-120 cyclotron. Neutron beam irradiation doses were within 2-17 Gy, x-ray doses from 7.5 to 72 Gy. Tumors were subjected to local irradiation with 1-8 fractions at a 3-4 day interval. The results showed that an increase in the total duration of a course of irradiation and a decrease in a dose per fraction resulted in a reduced effect of carcinoma growth inhibition. At the same time, an increase in the fast neutron RBE under these conditions from 3.4 (in single irradiation) to 5.4 (in 8-fold irradiation) indicated more pronounced inhibition of reparation and/or repopulation in a tumor in neutron beam irradiation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009368	Neoplasm Transplantation	Experimental transplantation of neoplasms in laboratory animals for research purposes.	Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D009502	Neutrons	Electrically neutral elementary particles found in all atomic nuclei except light hydrogen; the mass is equal to that of the proton and electron combined and they are unstable when isolated from the nucleus, undergoing beta decay. Slow, thermal, epithermal, and fast neutrons refer to the energy levels with which the neutrons are ejected from heavier nuclei during their decay.	Neutron
D011879	Radiotherapy Dosage	The total amount of radiation absorbed by tissues as a result of radiotherapy.	Dosage, Radiotherapy,Dosages, Radiotherapy,Radiotherapy Dosages
D012062	Relative Biological Effectiveness	The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.	Biological Effectiveness, Relative,Effectiveness, Biologic Relative,Effectiveness, Biological Relative,Relative Biologic Effectiveness,Biologic Effectiveness, Relative,Biologic Relative Effectiveness,Biological Relative Effectiveness,Effectiveness, Relative Biologic,Effectiveness, Relative Biological,Relative Effectiveness, Biologic
D002286	Carcinoma, Ehrlich Tumor	A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.	Ehrlich Ascites Tumor,Ascites Tumor, Ehrlich,Ehrlich Tumor Carcinoma,Tumor, Ehrlich Ascites
D005214	Fast Neutrons	Neutrons, the energy of which exceeds some arbitrary level, usually around one million electron volts.	Fast Neutron,Neutron, Fast,Neutrons, Fast
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus