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Cytotoxic and Anti-Inflammatory Sesquiterpenes from the Whole Plants of Centipeda minima. 2021
Peng-Hui Xue, and
Nan Zhang, and
Da Liu, and
Qing-Ran Zhang, and
Jing-Shi Duan, and
Ya-Qin Yu, and
Jin-Yan Li, and
Shi-Jie Cao, and
Feng Zhao, and
Ning Kang, and
Feng Qiu
School of Chinese Materia Medica and State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, People's Republic of China.
Sixteen new sesquiterpene lactones (1-16) along with 13 known analogues (17-29) were isolated from the whole plants of Centipeda minima. The structures of 1-16 were delineated by the combination of NMR spectroscopic experiments, HRESIMS, single-crystal X-ray diffraction analyses, and ECD spectra. Compounds 23-26 showed potent cytotoxicity against Hela, HCT-116, and HepG2 cells with IC50 values of 0.8-2.6, 0.4-3.3, and 1.1-2.6 μM, respectively. Compounds 8, 15, and 24 exhibited significant inhibitory activity on the production of nitric oxide in the lipopolysaccharide-activated RAW 264.7 mouse macrophage cell line, with IC50 values ranging from 0.1 to 0.2 μM.
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