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The synthesis, anti-inflammatory and antioxidant properties of novel 5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one derivatives were discussed. Fused thiazolo[4,5-b]pyridin-2-ones were synthesized and modified at the N3, C5 and C6 positions of the main core in order to obtain the compounds with a satisfactory pharmacological profile. The synthesized compounds were preselected via molecular docking for further testing of their anti-inflammatory activity in vitro. Evaluation of novel compounds over the carageenin induced rat paw edema revealed strong anti-inflammatory action of some compounds including (thiazolo[4,5-b]pyridin-3(2H)-yl) propanenitrile (5) and thiazolo[4,5-b]pyridin-3(2H)-yl) propanoic acid (6) even exceeding the standard - Ibuprofen. The antioxidant activity of the synthesized compounds was measured in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
January 1982,
Polish journal of pharmacology and pharmacy,
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
January 2010,
Journal of combinatorial chemistry,
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
December 2018,
Chemistry Central journal,
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
September 2023,
Scientific reports,
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
March 2015,
Journal of fluorescence,
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
January 1990,
Polish journal of pharmacology and pharmacy,
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
August 2017,
Bioorganic & medicinal chemistry letters,
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
December 2014,
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology,
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
January 1981,
Polish journal of pharmacology and pharmacy,
Taras I Chaban, and
Yulia E Matiichuk, and
Olga Ya Shyyka, and
Ihor G Chaban, and
Volodymyr V Ogurtsov, and
Ihor A Nektegayev, and
Vasyl S Matiychuk
June 2018,
Archiv der Pharmazie,
