The administration, in a double blind experiment, of piracetam to two homogeneous groups of 32 and 34 eight- to twelve-year-old brain-injured special education children lacking normal mental ability, where the daily doses administered for a period of thirteen weeks were 3 tablets or 1.2 g (administered to second and third graders) and 5 tablets or 2.0 g (administered to fourth graders), respectively, did not produce a lasting effect upon the capacity to acquire and apply knowledge, the concentration power, the proficiency level, and the behavior shown by pupils during and out of school hours. On the other hand, there was observed, in patients receiving placebos, a nonsignificant tendency toward improvement in physical well-being, so that the effect produced by the drug may here be considered to be a negative one.