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Patients with myeloproliferative disorders (MPD) are known to have some abnormalities of platelet glycoproteins (Gp). Quantitative changes of the Gp Ib, IIb-IIIa, and/or their glucidic content have been reported. Since the Gp IIb-IIIa complex plays a major role in fibrinogen binding by activated platelets, we measured the platelet fibrinogen affinity in nine patients with polycythemia vera (PV) and one subject with chronic myeloid leukemia (CML) by the aggregometric method of Marguerie. In all patients the Kd of the platelet fibrinogen reaction was significantly decreased as compared to controls, with evidence in two cases with PV of a heterogeneity of platelet-fibrinogen receptor sites. The measurement of 125I-labeled fibrinogen-platelet binding, performed in seven patients (five PV and two CML), showed receptor populations with increased (Kd1 = 0.58 + 0.3 X 10(7) mol/L) and normal affinity (Kd2 = 5.12 + 3.1 X 10(7) mol/L). These results demonstrate a heterogeneity of platelet-fibrinogen receptors in these patients and may explain the thrombotic diathesis of MPD subjects.
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
February 1972,
British journal of haematology,
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
December 1972,
Cancer,
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
May 2000,
Platelets,
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
February 1986,
Prostaglandins, leukotrienes, and medicine,
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
November 1995,
British journal of haematology,
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
May 1985,
Israel journal of medical sciences,
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
September 1978,
Blood,
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
June 1979,
Thrombosis and haemostasis,
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
December 1980,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
R Landolfi, and
R De Cristofaro, and
M Castagnola, and
E De Candia, and
G D'Onofrio, and
G Leone, and
B Bizzi
November 1990,
American journal of hematology,
