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A case of eosinophilic granuloma of the lymph nodes is reported. Two finger-tip-sized masses were recognized in the left postauricular region in a 4-month-old female. Both masses had distended peripheral sinuses occupied by proliferating cells with nuclear indentation. These foci were accompanied with a central necrosis and eosinophils that had infiltrated into the dermis, and were observed also in the efferent lymph duct. Immunohistochemically these cells were positive for S 100 beta, OKT 4, and OKT 6, and were weakly positive for S 100 alpha. These findings suggest that proliferating cells in the T-zone histiocyte lineage might have been somewhat different in this case from usual cases of eosinophilic granuloma.
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