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The in-vitro effects of bone marrow fibroblastic cells (FC) and fibroblastic conditioned medium (FCM) on the proliferation and differentiation of two human leukemic cell lines, HL-60 and KG-1 were studied. When FC were seeded onto only one-half of the culture dish an increase in colony size of HL-60 and KG-1 was observed directly above the FC. FCM had a greater effect, resulting in approximately a four-fold increase in the size of HL-60 and KG-1 colonies. In regards to colony number, FCM from normals inhibited HL-60, but FCM from other sources had no effect. FCM from both normals and ANLL in CR inhibited KG-1 colony number in contrast to the lack of effect with FCM from ANLL at diagnosis and RAEB. Neither FC nor FCM had any effect on the differentiation of either cell line. Our results indicate that FC modulate the proliferation of both HL-60 and KG-1. Furthermore, in ANLL the effects of FC are dependent upon the stage of the disease.
B R Greenberg, and
L Woo, and
H S Garewal
April 2005,
Zhongguo shi yan xue ye xue za zhi,
B R Greenberg, and
L Woo, and
H S Garewal
January 2021,
IUBMB life,
B R Greenberg, and
L Woo, and
H S Garewal
March 2021,
Tissue engineering. Part A,
B R Greenberg, and
L Woo, and
H S Garewal
November 1984,
In vitro,
B R Greenberg, and
L Woo, and
H S Garewal
April 2004,
Zhongguo shi yan xue ye xue za zhi,
B R Greenberg, and
L Woo, and
H S Garewal
April 2005,
Sheng li xue bao : [Acta physiologica Sinica],
B R Greenberg, and
L Woo, and
H S Garewal
December 1992,
Anti-cancer drugs,
B R Greenberg, and
L Woo, and
H S Garewal
October 1987,
Blood,
B R Greenberg, and
L Woo, and
H S Garewal
October 2010,
Neuroscience letters,
B R Greenberg, and
L Woo, and
H S Garewal
September 2000,
Human & experimental toxicology,
