-transparent.png){kind=logo}
RIFM low-exposure fragrance ingredients safety assessment. 2021
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
The existing information supports the use of these materials as described in this safety assessment. The 167 materials identified in this assessment were evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Target data, read-across analogs and TTC show that these materials are not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for their respective Cramer Classes (see Fig. 1 below) and the exposure to these materials is below the TTC. The skin sensitization endpoint was completed using the DST for non-reactive and reactive materials (900 μg/cm2 and 64 μg/cm2, respectively); exposures are below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; these materials are not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; the materials were found not to be PBT as per the IFRA Environmental Standards, and their risk quotients, based on their current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.
Related Publications
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
December 2002,
Regulatory toxicology and pharmacology : RTP,
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
September 1975,
The British journal of dermatology,
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
January 2010,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
December 2011,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
December 2013,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
July 2010,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
June 2017,
Regulatory toxicology and pharmacology : RTP,
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
October 2008,
Regulatory toxicology and pharmacology : RTP,
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
April 2003,
Regulatory toxicology and pharmacology : RTP,
A M Api, and
D Belsito, and
S Biserta, and
D Botelho, and
M Bruze, and
G A Burton, and
J Buschmann, and
M A Cancellieri, and
M L Dagli, and
M Date, and
W Dekant, and
C Deodhar, and
A D Fryer, and
S Gadhia, and
L Jones, and
K Joshi, and
A Lapczynski, and
M Lavelle, and
D C Liebler, and
M Na, and
D O'Brien, and
A Patel, and
T M Penning, and
G Ritacco, and
F Rodriguez-Ropero, and
J Romine, and
N Sadekar, and
D Salvito, and
T W Schultz, and
F Siddiqi, and
I G Sipes, and
G Sullivan, and
Y Thakkar, and
Y Tokura, and
S Tsang
April 2000,
Regulatory toxicology and pharmacology : RTP,
