Biomaterial Database

Prenatal PM2.5 exposure and neurodevelopment at 2 years of age in a birth cohort from Mexico city. 2021

Magali Hurtado-Díaz, and Horacio Riojas-Rodríguez, and Stephen J Rothenberg, and Lourdes Schnaas-Arrieta, and Itai Kloog, and Allan Just, and David Hernández-Bonilla, and Robert O Wright, and Martha Ma Téllez-Rojo

Center for Population Health Research, National Institute of Public Health, Av. Universidad No. 655, Col. Sta. Ma. Ahuacatitlán, 62100, Cuernavaca, Morelos, Mexico. Electronic address: mhurtado@insp.mx.

Recent studies have reported that air pollution exposure may have neurotoxic properties. To examine longitudinal associations between prenatal particles less than 2.5 μm in diameter (PM2.5) exposure and neurodevelopment during the first two years of children's life. Analysis was conducted in PROGRESS, a longitudinal birth cohort between 2007 and 2013 in Mexico City. We used satellite data to predict daily PM2.5 concentrations at high spatial resolution. Multivariate mixed-effect regression models were adjusted to examine cognitive, language and motor scores in children up to 24 months of age (n = 740) and each trimester-specific and whole pregnancy exposure to PM2.5. Models adjusted by child sex, gestational age, birth weight, smoking and mother's IQ, showed that each increase of 1 μg/m3 of PM2.5 was associated with a decreased language function of -0.38 points (95% CI: -0.77, -0.01). PM2.5 exposure at third trimester of pregnancy contributed most to the observed association. Our findings suggest that language development up to 24 months of age may be particularly sensitive to PM2.5 exposure during pregnancy.

UI	MeSH Term	Description	Entries
D008800	Mexico	A country in NORTH AMERICA, bordering the Caribbean Sea and the Gulf of Mexico, between BELIZE and the UNITED STATES, and bordering the North Pacific Ocean, between Guatemala and the UNITED STATES.
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011297	Prenatal Exposure Delayed Effects	The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.	Delayed Effects, Prenatal Exposure,Late Effects, Prenatal Exposure
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000393	Air Pollutants	Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or materials. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.	Air Pollutant,Air Pollutants, Environmental,Environmental Air Pollutants,Environmental Pollutants, Air,Air Environmental Pollutants,Pollutant, Air,Pollutants, Air,Pollutants, Air Environmental,Pollutants, Environmental Air
D000397	Air Pollution	The presence of contaminants or pollutant substances in the air (AIR POLLUTANTS) that interfere with human health or welfare, or produce other harmful environmental effects. The substances may include GASES; PARTICULATE MATTER; or volatile ORGANIC CHEMICALS.	Air Quality,Air Pollutions,Pollution, Air
D052638	Particulate Matter	Particles of any solid substance, generally under 30 microns in size, often noted as PM30. There is special concern with PM1 which can get down to PULMONARY ALVEOLI and induce MACROPHAGE ACTIVATION and PHAGOCYTOSIS leading to FOREIGN BODY REACTION and LUNG DISEASES.	Ultrafine Fiber,Ultrafine Fibers,Ultrafine Particle,Ultrafine Particles,Ultrafine Particulate Matter,Air Pollutants, Particulate,Airborne Particulate Matter,Ambient Particulate Matter,Fiber, Ultrafine,Particle, Ultrafine,Particles, Ultrafine,Particulate Air Pollutants,Particulate Matter, Airborne,Particulate Matter, Ambient,Particulate Matter, Ultrafine
D018811	Maternal Exposure	Exposure of the female parent, human or animal, to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals that may affect offspring. It includes pre-conception maternal exposure.	Exposure, Maternal,Exposures, Maternal,Maternal Exposures