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Acid phosphatase activity, ATP and cyclic nucleotide levels were studied in primary cardiomyocyte cultures of newborn rats under hypoxic conditions. It was shown that incubation of cardiac cells in Eagle's medium supplemented with 10% calf serum during hypoxia (5% O2, 5% CO2, 90% N2) caused an hour later a decrease in lysosomal acid phosphatase activity, whereas free enzyme activity increased. The exposure of cells in Hanks salt solution to one hour hypoxia resulted in a 3-fold decrease of ATP level and further increase in free acid phosphatase activity. It was found that cAMP and cGMP levels do not depend on the presence of hypoxia. The mechanisms involved in the regulation of lysosomal membrane state are discussed.
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
January 1985,
Izvestiia Akademii nauk SSSR. Seriia biologicheskaia,
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
March 1996,
Journal of cardiovascular pharmacology,
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
May 1968,
Canadian journal of zoology,
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
March 1989,
Journal of biochemistry,
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
January 1983,
Acta physiologica Polonica,
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
January 1991,
Fiziologicheskii zhurnal,
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
March 1990,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
August 1990,
Journal of biochemistry,
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
April 1994,
Cell calcium,
B F Korovkin, and
E D Poliakova, and
N S Stvolinskaia, and
Ts I Gerasimova, and
T N Ivanova
January 1967,
Archives de biologie,
