Biomaterial Database

Vascular Endothelial Protein Tyrosine Phosphatase Regulates Endothelial Function. 2021

Dietmar Vestweber

Max Planck Institute of Molecular Biomedicine, Münster, Germany.

Vascular endothelial protein tyrosine phosphatase (VE-PTP) is a receptor-type PTP (RPTP), predominantly expressed in vascular endothelial cells. It regulates embryonic and tumor angiogenesis and controls vascular permeability and homeostasis in inflammation. Major substrates are the tyrosine kinase receptor Tie-2 and the adhesion molecule VE-cadherin. This review describes how VE-PTP controls vascular functions by its various substrates and the therapeutic potential of VE-PTP in various pathophysiological settings.

UI	MeSH Term	Description	Entries
D010766	Phosphorylation	The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.	Phosphorylations
D002199	Capillary Permeability	The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.	Microvascular Permeability,Permeability, Capillary,Permeability, Microvascular,Vascular Permeability,Capillary Permeabilities,Microvascular Permeabilities,Permeabilities, Capillary,Permeabilities, Microvascular,Permeabilities, Vascular,Permeability, Vascular,Vascular Permeabilities
D004730	Endothelium, Vascular	Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.	Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D042783	Endothelial Cells	Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.	Capillary Endothelial Cells,Lymphatic Endothelial Cells,Vascular Endothelial Cells,Capillary Endothelial Cell,Cell, Capillary Endothelial,Cell, Endothelial,Cell, Lymphatic Endothelial,Cell, Vascular Endothelial,Cells, Capillary Endothelial,Cells, Endothelial,Cells, Lymphatic Endothelial,Cells, Vascular Endothelial,Endothelial Cell,Endothelial Cell, Capillary,Endothelial Cell, Lymphatic,Endothelial Cell, Vascular,Endothelial Cells, Capillary,Endothelial Cells, Lymphatic,Endothelial Cells, Vascular,Lymphatic Endothelial Cell,Vascular Endothelial Cell
D054631	Receptor-Like Protein Tyrosine Phosphatases, Class 3	A subclass of receptor-like protein tryosine phosphatases that contain a single cytosolic protein tyrosine phosphate domain and multiple extracellular fibronectin III-like domains.	Protein Tyrosine Phosphatase, Receptor Type B,Protein Tyrosine Phosphatase, Receptor Type H,Protein Tyrosine Phosphatase, Receptor Type J,Protein Tyrosine Phosphatase, Receptor Type O,Protein Tyrosine Phosphatase, Receptor Type Q,Protein Tyrosine Phosphatase, Receptor Type V,DEP1 Phosphatase,Density-Enhanced Phosphatase 1,GLEPP1 Phosphatase,Glomerular Epithelial Protein 1,PTPRB Phosphatase,PTPRH Phosphatase,PTPRJ Phosphatase,PTPRO Phosphatase,PTPRQ Phosphatase,PTPRV Phosphatase,Protein Tyrosine Phosphatase Receptor omicron,Protein-Tyrosine Phosphatase eta,Receptor-Like Protein Tyrosine Phosphatases, Class III,SAP-1 Phosphatase,Stomach Cancer-Associated Protein-Tyrosine Phosphatase,VE-PTP Phosphatase,Vascular Endothelial Protein Tyrosine Phosphatase,Density Enhanced Phosphatase 1,Phosphatase eta, Protein-Tyrosine,Phosphatase, GLEPP1,Phosphatase, PTPRB,Phosphatase, PTPRH,Phosphatase, PTPRJ,Phosphatase, PTPRO,Phosphatase, PTPRQ,Phosphatase, PTPRV,Phosphatase, SAP-1,Protein Tyrosine Phosphatase eta,Receptor Like Protein Tyrosine Phosphatases, Class 3,Receptor Like Protein Tyrosine Phosphatases, Class III,SAP 1 Phosphatase,Stomach Cancer Associated Protein Tyrosine Phosphatase,VE PTP Phosphatase