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A preliminary study was conducted with netilmicin, a new aminoglycoside antibiotic. Its effectiveness was evaluated in vitro against 546 strains of Enterobacteriaceae and Pseudomonas aeruginosa isolated from clinical material. Its effectiveness against gentamicin-susceptible strains was roughly similar to that of gentamicin and other newer aminoglycoside antibiotics. Cross-resistance to netilmicin was found in 9 of 44 gentamicin-resistant strains. A favorable clinical response was observed in 70% of the patients treated with a dose of netilmicin ranging from 4.5 to 7.5 mg/kg. However, the appearance of granular casts was seen in 7 of 10 patients receiving the higher dosage of netilmicin (7.5 mg/kg) and a rise in blood urea nitrogen or serum creatinine levels was observed in 5 of these patients.
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L Coppens-Kahan, and
D Daneau, and
J M Prevost
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J Klastersky, and
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J Klastersky, and
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J Klastersky, and
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J M Prevost
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J Klastersky, and
F Meunier-Carpentier, and
L Coppens-Kahan, and
D Daneau, and
J M Prevost
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J Klastersky, and
F Meunier-Carpentier, and
L Coppens-Kahan, and
D Daneau, and
J M Prevost
January 1981,
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J Klastersky, and
F Meunier-Carpentier, and
L Coppens-Kahan, and
D Daneau, and
J M Prevost
January 1983,
Clinical therapeutics,
