-transparent.png){kind=logo}
This preliminary study was conducted to evaluate the effects of 0.02 mg/kg of epinephrine (E) on myocardial blood flow (MBF), myocardial oxygen consumption (MVO2), and delivery (MDO2) when administered during CPR after 10-min cardiopulmonary arrest. Five miniature swine were instrumented for MBF measurements using tracer microspheres. Ventricular fibrillation was induced. After 10 min, CPR was begun with a pneumatic compressor. Measurements of MBF, arterial, and coronary sinus blood gases were made. After 3 min of CPR, each animal received 0.02 mg/kg of E. The measurements were repeated and defibrillation was attempted. During CPR, MDO2 and MVO2 were 0.2 +/- 0.3 and 0.2 +/- 0.3 ml/min/100 g tissue, respectively. The myocardial oxygen extraction ratio (ER) was 94.2 +/- 3.0%. After 0.02 mg/kg of E, MDO2 was 1.1 +/- 1.4, MVO2 was 1.0 +/- 1.3, and ER was 93.9 +/- 0.7% (p greater than .05). There were no successful defibrillations. These data indicate that MDO2 improves slightly during CPR after 0.02 mg/kg of E, but it does not meet the oxygen demands of the fibrillating heart.
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
June 1990,
Chest,
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
January 1991,
The American journal of emergency medicine,
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
February 1987,
Circulation,
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
March 1991,
JAMA,
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
August 1992,
Cardiovascular research,
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
December 1991,
International journal of cardiology,
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
December 2014,
BMC cardiovascular disorders,
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
September 2005,
Resuscitation,
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
January 2000,
Annals of emergency medicine,
C G Brown, and
R B Taylor, and
H A Werman, and
T Luu, and
G Spittler, and
R L Hamlin
January 2024,
Journal of the American Heart Association,
