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The effects of low level phenobarbital administration (18 postcoitus to 21 days postnatal) on Purkinje cell growth and remodeling were studied from 3 to 20 weeks postnatal). The Purkinje cell dendritic trees were analyzed both metrically and topologically using the method of vertex analysis. The total segment length, mean terminal path length, and mean vertex path length were reduced in the treated cells. The pattern of segment frequency as related to equivalent orders was abnormal in the treated cells. The Va/Vb vertex ratios and the levels of trichotomy indicated that the treated cells underwent nonrandom remodeling, unlike the control cells which exhibited dichotomous, random terminal branching. These observations confirm that phenobarbital produces distinct long-term morphologic alterations in Purkinje cells.
R S Hannah, and
S H Roth, and
A W Spira
January 1983,
Basic and applied histochemistry,
R S Hannah, and
S H Roth, and
A W Spira
July 2008,
The Malaysian journal of medical sciences : MJMS,
R S Hannah, and
S H Roth, and
A W Spira
December 2002,
Brain research. Developmental brain research,
R S Hannah, and
S H Roth, and
A W Spira
January 1981,
Bioelectromagnetics,
R S Hannah, and
S H Roth, and
A W Spira
January 1983,
Basic and applied histochemistry,
R S Hannah, and
S H Roth, and
A W Spira
April 1981,
Neuropharmacology,
R S Hannah, and
S H Roth, and
A W Spira
December 1980,
The Journal of comparative neurology,
R S Hannah, and
S H Roth, and
A W Spira
May 2006,
The European journal of neuroscience,
R S Hannah, and
S H Roth, and
A W Spira
January 1985,
Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie,
R S Hannah, and
S H Roth, and
A W Spira
October 1999,
Alcoholism, clinical and experimental research,
