BIOMAT Database Logo BIOMAT Database Logo

Reactivation of hepatitis B virus in anti-HBe-positive chronic active type B hepatitis: molecular and immunohistochemical studies. 1988

M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
Department of Internal Medicine, National Taiwan University College ofMedicine, Republic of China.

The causes of acute clinical exacerbations, and the role of reactivation of hepatitis B virus (HBV) in 16 non-cirrhotic patients with chronic active type B hepatitis (CAH-B) negative for serum hepatitis B e antigen (HBeAg) but positive for anti-HBE, were studied by molecular hybridization and immunohistochemical methods. IgM antibody to hepatitis A virus (anti-HAV IgM) and antibody to delta agent (anti-delta) were negative in all. HBeAg reappeared transiently in only two patients. Serum hepatitis B virus (HBV) DNA levels increased during acute exacerbations in 14 patients (88%), and decreased after the episode. Cytoplasmic hepatitis B core antigen (HBcAg) expression was found in 9 out of 13 patients (69%) during acute exacerbation. By Southern blot hybridization, 5 of 6 (83%) liver tissues obtained during clinical exacerbations had free replicative forms of HBV DNA. In 20 control patients with no exacerbation, serum HBV DNA, HBcAg expression in hepatocytes and free replicative forms of HBV DNA were positive in 15% (3/20), 10% (2/20) and 25% (2/8), respectively--figures significantly lower than those of the group studied. We conclude that acute exacerbations sometimes seen in patients with anti-HBe-positive CAH-B in Taiwan are caused mainly by reactivation of HBV.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D005260 Female Females
D006509 Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis B Virus Infection
D006510 Hepatitis B Antibodies Antibodies to the HEPATITIS B ANTIGENS, including antibodies to the surface (Australia) and core of the Dane particle and those to the "e" antigens. Anti-Australia Antigens,Anti-HBAg,Anti-Hepatitis B Antigens,Anti HBAg,Hepatitis B Virus Antibodies,Anti Australia Antigens,Anti Hepatitis B Antigens,Antibodies, Hepatitis B,Antigens, Anti-Australia,Antigens, Anti-Hepatitis B,B Antibodies, Hepatitis,B Antigens, Anti-Hepatitis,HBAg, Anti
D006512 Hepatitis B Core Antigens The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion. HBcAg,Hepatitis B Core Antigen
D006513 Hepatitis B e Antigens A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic hepatitis B, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins G. HBeAg,Hepatitis B e Antigen,Hepatitis Be Antigen,e Antigen,e Antigens,HBe Ag-1,HBe Ag-2,Hepatitis Be Antigens,Antigen, Hepatitis Be,Antigen, e,Antigens, Hepatitis Be,Antigens, e,Be Antigen, Hepatitis,Be Antigens, Hepatitis
D006515 Hepatitis B virus The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum. Dane Particle,Hepatitis Virus, Homologous Serum,B virus, Hepatitis,Hepatitis B viruses,Particle, Dane,viruses, Hepatitis B
D006521 Hepatitis, Chronic INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors. Chronic Hepatitis,Cryptogenic Chronic Hepatitis,Hepatitis, Chronic, Cryptogenic,Hepatitis, Chronic Active,Hepatitis, Chronic Persistent,Chronic Active Hepatitis,Chronic Hepatitis, Cryptogenic,Chronic Persistent Hepatitides,Chronic Persistent Hepatitis,Hepatitis, Cryptogenic Chronic

Related Publications

M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
[Reactivation of hepatitis B virus in chronic carriers with anti-HBe].
June 1991, Revista clinica espanola,
M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
[Clinical significance of hepatitis B virus precore/core mutants in HBe-antigen-positive and anti-HBe-positive chronic hepatitis B].
October 1995, Nihon rinsho. Japanese journal of clinical medicine,
M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
Long-term follow-up of anti-HBe-positive chronic active hepatitis B.
January 1988, Hepatology (Baltimore, Md.),
M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
[Prognosis of anti-HBe positive chronic hepatitis B].
October 1995, Nihon rinsho. Japanese journal of clinical medicine,
M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
Intrahepatic lymphocyte subpopulation defined by monoclonal antibodies in anti-HBe positive type B chronic active hepatitis.
October 1985, Gastroenterologia Japonica,
M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
Interferon treatment of anti-HBe positive and HBV-DNA positive chronic hepatitis type B.
July 1989, Journal of chemotherapy (Florence, Italy),
M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
Detection of HBeAg/anti-HBe immune complexes in the reactivation of hepatitis B virus replication among anti-HBe chronic carriers.
April 1990, Liver,
M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
[Mutation in the pre-C gene of hepatitis B virus and anti-HBE positive chronic hepatitis B].
May 1992, Zhonghua nei ke za zhi,
M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
IgM anti-HBc in anti-HBe positive chronic type B hepatitis with acute exacerbations.
January 1987, Hepatology (Baltimore, Md.),
M Y Lai, and D S Chen, and S C Lee, and I J Su, and P M Yang, and H C Hsu, and J L Sung
A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B.
March 1990, Journal of hepatology,
Copied contents to your clipboard!