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An investigation into the combined effects of X-irradiation and 3MHz ultrasound-induced hyperthermia on pig skin. 1988

G ter Haar, and J W Hopewell
Physics Department, Institute of Cancer Research, Sutton, Surrey, U.K.

The thermal enhancement of radiation-induced damage in pig skin has been investigated. Heating at 43 degrees C for 60 min was produced by a scanned 3MHz ultrasound transducer, immediately after single doses of X rays. The ED50 values for the dermal reactions of dusky/mauve erythema and necrosis after irradiation alone were 18.6 +/- 0.5 Gy and 20.5 +/- 0.4 Gy, respectively. The reduction in the ED50 values to 15.3 +/- 0.4 Gy and 17.7 +/- 0.5 Gy after irradiation plus heating was significant and suggested a thermal enhancement ratio (TER) of between 1.15 and 1.22. These TER values were within the range obtained in both pig and rat skin using other 'dry' heating methods. This would suggest that the non-thermal effects of ultrasound do not influence the thermal enhancement of x-irradiation damage.

UI MeSH Term Description Entries
D006979 Hyperthermia, Induced Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs. Fever Therapy,Hyperthermia, Local,Hyperthermia, Therapeutic,Thermotherapy,Induced Hyperthermia,Therapeutic Hyperthermia,Therapy, Fever,Local Hyperthermia
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012867 Skin The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D014465 Ultrasonics A subfield of acoustics dealing in the radio frequency range higher than acoustic SOUND waves (approximately above 20 kilohertz). Ultrasonic radiation is used therapeutically (DIATHERMY and ULTRASONIC THERAPY) to generate HEAT and to selectively destroy tissues. It is also used in diagnostics, for example, ULTRASONOGRAPHY; ECHOENCEPHALOGRAPHY; and ECHOCARDIOGRAPHY, to visually display echoes received from irradiated tissues. Ultrasonic

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