-transparent.png){kind=logo}
Pancreatic microcirculation in acute pancreatitis and the effect of dopamine and pancreatic protease inhibitor were investigated in 35 mongrel dogs. Acute pancreatitis was induced by the injection of autologous bile added trypsin into pancreatic duct. In acute pancreatitis dogs femoral artery pressure and pulse pressure gradually decreased and pancreatic microflow in basal state temporarily increased immediately after bile injection, however, thereafter continuously decreased during the experiments. Portal flow severely decreased just after onset of acute pancreatitis. By administration of dopamine femoral artery pressure was maintained during the first 90 minutes of experiments, however, thereafter decreased until the end of experiments. Pancreatic microflow, 56.1 +/- 15.3 ml/min/100g in basal level was shown 66.1 +/- 13.7 and 60.3 +/- 10.3 ml/min/100g at 1 and 2 hours, respectively, after bile injection, which were significantly high values as compared with those of non dopamine administration. However those values decreased at 5 hours of both experiments. Portal flow whose basal level was 237 +/- 67 ml/min was maintained during the first 1 hour however it decreased to 139 +/- 25 ml/min at 5 hours. By administration of pancreatic protease inhibitor femoral artery pressure and pulse pressure, temporarily decreased immediately after bile injection, however, they were maintained thereafter. Pancreatic microflow, 57.1 +/- 18.3 ml/min/100g in basal level, was maintained during the first 2 hours, however significantly decreased to 27.6 +/- 9.7 ml/min/100g at 5 hours. Portal flow significantly increased to 442 +/- 115 ml/min at 2 hours, however, thereafter decreased 219 +/- 93 ml/min at 5 hours.(ABSTRACT TRUNCATED AT 250 WORDS)
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
January 1998,
Journal of hepato-biliary-pancreatic surgery,
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
May 1996,
The Journal of surgical research,
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
March 2001,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
January 1984,
Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR,
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
February 1993,
Surgery, gynecology & obstetrics,
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
September 1994,
Journal of the American College of Surgeons,
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
February 2006,
World journal of gastroenterology,
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
May 2013,
Gut and liver,
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
May 2006,
The British journal of surgery,
H Nishiwaki, and
K Satake, and
I Ko, and
K Umeyama
November 1981,
Digestive diseases and sciences,
